ε-Caprolactone in micro-chambered ceramic beads--a new carrier for gentamicin.
نویسندگان
چکیده
PURPOSE The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. METHODS The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied. RESULTS AND DISCUSSION Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts.
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ورودعنوان ژورنال:
- Chemotherapy
دوره 59 4 شماره
صفحات -
تاریخ انتشار 2013